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Principal component analysis clearly demonstrates that duration of BDG exposure (PC1) has a major effect on monocyte gene expression ( Figure 2A )

Your body can reassemble these into glutathione, but this is a slow, rate-limited process

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The loss of redox homeostatic balance in the brain in the presence of increased ROS or reduced GSH and similar antioxidant molecules may suggest a pro-inflammatory aetiology in MDD